Research
<<Back to Main Research Page
1: Expert Rev Neurother. 2005 Jul;5(4):437-41.
Dexmethylphenidate extended-release capsules for
attention deficit hyperactivity disorder.
McGough JJ, Pataki CS, Suddath R.
David Geffen School of Medicine, 300 UCLA Medical Plaza,
Suite 1414, Los Angeles, CA 90095, USA. jmcgough@mednet.ucla.edu
Medications for attention deficit hyperactivity disorder
(ADHD) currently represent the ninth largest segment of the
CNS market by sales, with 2.4 billion USD spent annually on
this condition and 40% annual growth. Stimulant medications
remain the most effective ADHD therapies and provide robust
improvement in ADHD symptoms in both youth and adults. Current
prescribing practices favor extended release preparations
due to increased convenience, compliance and tolerability
with once-daily dosing. Dexmethylphenidate extended release
is a long-acting preparation of the ADHD medication Focalin
(dexmethylphenidate immediate release) and was approved for
marketing by the US Food and Drug administration in June 2005.
Dexmethylphenidate consists of the single dextro-isomer form
of d,l-methylphenidate commonly marketed as Ritalin. Dexmethylphenidate
extended release utilizes spheroidal oral drug absorption
system technology to achieve a 50% immediate medication delivery
and 50% delayed release of dexmethylphenidate approximately
4 h after ingestion. Placebo-controlled, clinical trials in
children and adults with ADHD have demonstrated efficacy for
behavioral and academic ratings, with an analog classroom
study showing medication effects up to 12 h after dosing.
Dexmethylphenidate extended release was generally well tolerated
with a side-effect profile similar to other stimulants. The
most common reported side effects include diminished appetite
and insomnia. Given its duration of effect, favorable tolerability
and flexibility in dosing, dexmethylphenidate extended release
is likely to gain considerable use as an ADHD treatment.
PMID: 16026226 [PubMed - indexed for MEDLINE]
<<Back to Main Research Page
 __________________________________________________________
|
