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Free Radic Biol Med. 2007 Apr 1;42(7):945-54. Epub 2006 Dec
9.
Phosphatidylserine and phosphatidylcholine-containing
liposomes inhibit amyloid beta and interferon-gamma-induced
microglial activation.
Hashioka S, Han YH, Fujii S, Kato T, Monji A, Utsumi H,
Sawada M, Nakanishi H, Kanba S.
Department of Neuropsychiatry, Graduate School of Medical
Sciences, Kyushu University, Fukuoka, Japan. hashioka@interchange.ubc.ca
There is increasing evidence that microglial activation
is one of the major pathogenic factors for Alzheimer's disease
(AD) and the inhibition of the inflammatory activation of
the microglia thus appears to be neuroprotective and a potentially
useful treatment for AD. Phospholipids such as phosphatidylserine
(PS) and phosphatidylcholine (PC) have been reported to modulate
the immune function of phagocytes. In addition, PS has been
reported to be a nootropics that can be used as nonprescription
memory or cognitive enhancers. We therefore evaluated the
effects of liposomes, which comprise both PS and PC (PS/PC
liposomes), on the microglial production of tumor necrosis
factor-alpha (TNF-alpha), nitric oxide (NO), and superoxide
(*O(2)-) induced by amyloid beta (Abeta) and interferon-gamma
(IFN-gamma). Pretreatment of microglia with PS/PC liposomes
considerably inhibited the TNF-alpha, NO and *O(2)- production
induced by Abeta/IFN-gamma. These results suggest that PS/PC
liposomes have both neuroprotective and antioxidative properties
through the inhibition of microglial activation, thus supporting
the nootropic and antidementia effect of PS.
PMID: 17349923 [PubMed - indexed for MEDLINE]
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